Molecular Biophysics
GITAM University, Bengaluru
My primary research focused on the fascinating field of Solvation Sciences, exploring the intermolecular interactions between solute and solvent molecules. Within the realm of biomolecular phenomena like protein folding, aggregation, fibrilization, and cryopreservation, solvation plays a crucial yet inconspicuous role.
Our goal is to understand how the structure and dynamics of water evolve around the hydrophilic and hydrophobic parts of biomolecules.
#hydrophobic hydration #protein folding #cryopreservation
Research Interests
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Solvation science: intermolecular interactions in biomolecular processes (electrolytes, co-solutes, co-solvents, cryoprotectants, macromolecules, proteins etc.) with a combination of experiments and MD simulation techniques.
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Role of solvent molecules in excited state proton transfer.
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Low-temperature hydrogen-bond dynamics in cryoprotectant systems.
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Structural stability and hydration dynamics of proteins in crowded environments.
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Temperature-dependent solvent-mediated interactions in cryoprotectants.
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Hydrophobic hydration, low-temperature H-bond dynamics, micro-heterogeneity, and self-assembly of biomolecules.